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Stereoselective Synthesis of cis-5-Alkyl-(S)-prolines from (S)-Pyroglutamic Acid via 5-Alkyl-5-hydroxy-(S)-prolines

✍ Scribed by Hao Li; Takeshi Sakamoto; Yasuo Kikugawa


Book ID
104257892
Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
553 KB
Volume
38
Category
Article
ISSN
0040-4039

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ChemInform Abstract: Stereoselective Syn
✍ H. LI; T. SAKAMOTO; Y. KIKUGAWA πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 30 KB πŸ‘ 2 views

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Stereoselective synthesis of (2S,3S,4R,5
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A catalytic deuteration of protected 3,4-dehydro-L-proline using RuCI2(PPh3) 3 followed by RuO~-oxidation gave a 3,4-dideuterated L-pyroglutamic acid derivative which is considered to be a promising precursor for various deuterated amino acids. The present study demonstrates a stereoselective reduct