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Stereoselective synthesis of a synthon for the A-ring of taxol from R-(+)-verbenone

โœ Scribed by Jeffrey D. Winkler; Samit K. Bhattacharya; Fina Liotta; Robert A. Batey; Gavin D. Heffernan; David E. Cladingboel; Robert C. Kelly


Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
225 KB
Volume
36
Category
Article
ISSN
0040-4039

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Taxol Synthesis: Synthesis of A-Ring and a Methodology for Substituted Cyclohexadienes. -Key step in the synthesis of taxol-A ring synthon (IV) is a Michael/Wittig reaction for the construction of the cyclohexadiene skeleton. Further studies concerning this reaction reveal that the method is a gene