✦ LIBER ✦

Stereoselective synthesis of a functionalised bicyclic core of Neocarzinostatin and Kedarcidin Chromophores

✍ Scribed by Stephen Caddick; Vern M. Delisser

Book ID: 104256716
Publisher: Elsevier Science
Year: 1997
Tongue: French
Weight: 316 KB
Volume: 38
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(97)00347-x

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✦ Synopsis

The sterem&ctive synthesis of a bicyclic ring system related to Neocarzinostatin and Kedarcidin Chromophonzs is described; key steps involve stereoselective conjugate addition of an enediyne to an enone and intramolecular aldol reaction of a cobalt complexed allcynyl aIdehyde. 0 1997 Elsevier Science Ltd.

The enediyne class of anti-cancer antibiotics have stimulated great interest in chemical synthesis, medicine and biology because of their biological activity which is dependant on activation of the unusual enediyne or dienediyne structural motif.' Our present research effort in this area focuses on studies toward the

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