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Stereoselective synthesis of 9-trans-9-Desmethyl-9-fluororetinals based on the four-components coupling approach

โœ Scribed by Tetsuro Shinada; Noriko Sekiya; Nina Bojkova; Kazuo Yoshihara


Book ID
108379203
Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
676 KB
Volume
55
Category
Article
ISSN
0040-4020

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โœ M Venkatachalam; S Wehrli; G Kubiak; J.M Cook; U Weiss ๐Ÿ“‚ Article ๐Ÿ“… 1986 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 280 KB

The synthesis of polyquinane 2 is described. The key steps were the Wolff-Kishner reduction of & to provide m, and the acetic, sulfuric acid-mediated aldol cyclization to convert the bisacetal 11 into the target 2. Olefin isomerization during the Wolff-Kishner reduction was overcome by addition of A