Discovery and Development of the Novel Potent Orally Active Thrombin Inhibitor N -(9-Hydroxy-9-fluorenecarboxy)prolyl trans -4-Aminocyclohexylmethyl Amide (L-372,460): Coapplication of Structure-Based Design and Rapid Multiple Analogue Synthesis on Solid Support

✍ Scribed by Brady, Stephen F.; Stauffer, Kenneth J.; Lumma, William C.; Smith, Graham M.; Ramjit, Harri G.; Lewis, S. Dale; Lucas, Bobby J.; Gardell, Steven J.; Lyle, Elizabeth A.; Appleby, Sandra D.; Cook, Jacquelynn J.; Holahan, Marie A.; Stranieri, Maria T.; Lynch, Joseph J.; Lin, Jiunn H.; Chen, I.-Wu; Vastag, Kari; Naylor-Olsen, Adel M.; Vacca, Joseph P.

• Book ID: 127288629
• Publisher: American Chemical Society
• Year: 1998
• Tongue: English
• Weight: 183 KB
• Volume: 41
• Category: Article
• ISSN: 0022-2623
• DOI: 10.1021/jm9705014