Stereoselective synthesis of 6,5-bicyclic reverse-turn peptidomimetics
โ Scribed by Lino Colombo; Marcello Di Giacomo; Gloria Brusotti; Nicola Sardone; Mauro Angiolini; Laura Belvisi; Sonia Maffioli; Leonardo Manzoni; Carlo Scolastico
- Book ID
- 108378970
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- French
- Weight
- 623 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0040-4020
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The flmt short syntheds of the @eptIde mimetic (3s. 8S. SS)-8-amlnc-6-oxctndotiridiW-cafhoxyfk add 1 and its zpmtected dedvatlve 9 is described, empkyfng the Schoallkcpf bkkctim-ether methodokgy, folkwed by a highly specific lntramokcufar reductive afnfnatkn and spontaneous kctamizatlon. These W-fus
Chemo-selective reduction of the pyroglutamate ring carbonyl in a serine-pyroglutamate or homoserine to pyroglutamate dipeptide gave a hemiaminal. Treatment of the hemiaminal with a catalytic amount of TFA in CH 2 Cl 2 generated an N-acyliminium ion that was intramolecularly trapped by the side-chai
Peptide side chains play critical roles in the event of molecular recognition. In order to study the bioactive conformation of parent peptides, a concise and straightforward five-step synthesis of [5.5]-bicyclic reverse turn dipeptide mimetic scaffolds with side chain functionality at the i+1 and i