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Stereoselective synthesis of (2S,3S)-3-hydroxy-2-phenylpiperidines, precursors of non-peptidic substance P antagonists

✍ Scribed by Olivier Calvez; Nicole Langlois

Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 129 KB
Volume: 40
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(99)01462-8

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✦ Synopsis

2S)-N-Boc-3-oxo-2-phenylpiperidine 5 and (2S,3S)-N-Boc-3-hydroxy-2-phenylpiperidine 6, known chiral building blocks for the synthesis of non-peptidic substance P antagonists, were prepared from erythro (2S)-N-benzyl 2-hydroxybenzylpyrrolidine derived from (S)-N-methoxy-N-methylpyroglutamide.

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