Stereoselective synthesis of 2-amino-1-hydroxy-3-phenylpropylphosphonic acid
β Scribed by Jan Zygmunt; Roman Gancarz; Barbara Lejczak; Piotr Wieczorek; Pawel Kafarski
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 212 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0960-894X
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β¦ Synopsis
A highly stereoselective synthesis of 2-amino-l-hydroxy-3-phenylpropylphosphonic acid was achieved by simple addition of diethyl phosphite to enantiomeric N-blocked phenylalanlnals. These compouds exhibit sit, nificant herbicidal activity.
π SIMILAR VOLUMES
Diastereoselectivemethylationof the ketone 5a leads ro the anti-derivative4a; the other diastereoisomer 4b may be obrained by a deprotonatiotrheprotonationsequence. Each of the methylatedproductsmay be reducedstereoselectivelyin either sense by appropriatechoice of reagent, providinga route to all s