Hydrogenation of (R)-cyanohydrins (R)-I with LiAIH4 occurs without racemization to give the (R)-2-amino alcohols (R)-3. (1R,2S)-2-Amino alcohols (1R,2S)-4 are obtained with high diastereoselectivity by addition of methyl Grignard to Osilyl protected cyanohydrins (R)-2 and subsequent hydrogenation wi
Stereoselective synthesis of (1R,2S)-2-amino-1,3-diols from (R)-cyanohydrins
✍ Scribed by Franz Effenberger; Beate Gutterer; Jana Syed
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 592 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0957-4166
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