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ChemInform Abstract: Enzyme-Catalyzed Reactions. Part 26. Stereoselective Synthesis of (1R)- and (1R,2S)-1-Aryl-2-alkylamino Alcohols from (R)-Cyanohydrins.

✍ Scribed by F. EFFENBERGER; B. GUTTERER; J. JAEGER


Publisher
John Wiley and Sons
Year
2010
Weight
30 KB
Volume
28
Category
Article
ISSN
0931-7597

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✦ Synopsis


Enzyme-Catalyzed Reactions. Part 26. Stereoselective Synthesis of (1R)-and (1R,2S)-1-Aryl-2-alkylamino Alcohols from (R)-Cyanohydrins.

-Enantiomerically pure N-alkylated amino alcohols are prepared from cyanohydrins, accessible by (R)-oxynitrilase catalyzed addition of HCN to the appropriate aldehydes as previously reported. The title compounds are sympathomimetics of pharmacological interest. -(EFFENBERGER, F.;


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