## Abstract This report describes an efficient stereoselective synthesis of [11Ξ²β^3^H]prostaglandin E~1~ ([11Ξ²β^3^H]PGE~1~). The key multiply protected 11βketo intermediate was prepared in only three steps from PGE~1~. Reduction of the ketone function at Cβ11 with sodium borodeuteride and sodium bo
β¦ LIBER β¦
Stereoselective synthesis of 11-deoxyprostaglandin E1
β Scribed by Kiyosi Kondo; Teruo Umemoto; Yuriko Takahatake; Daiei Tunemoto
- Publisher
- Elsevier Science
- Year
- 1977
- Tongue
- French
- Weight
- 215 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0040-4039
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In an earlier communication ' from our laboratory we reported the total synthesis of a physiologically active analogue (V) of prostaglandin. The ssymmetric centres C-8, C-9 and C-l.2 were assumed to have configurations shown in the formula. In this communication, we report an improved synthesis and