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Stereoselective synthesis of 11-deoxyprostaglandin E1

✍ Scribed by Kiyosi Kondo; Teruo Umemoto; Yuriko Takahatake; Daiei Tunemoto


Publisher
Elsevier Science
Year
1977
Tongue
French
Weight
215 KB
Volume
18
Category
Article
ISSN
0040-4039

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## Abstract This report describes an efficient stereoselective synthesis of [11β‐^3^H]prostaglandin E~1~ ([11β‐^3^H]PGE~1~). The key multiply protected 11‐keto intermediate was prepared in only three steps from PGE~1~. Reduction of the ketone function at C‐11 with sodium borodeuteride and sodium bo

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