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Stereoselective Synthesis of 1-Bromo-1-fluorostyrenes

✍ Scribed by Aleksey V. Shastin; Vasiliy M. Muzalevsky; Elizabeth S. Balenkova; Valentine G. Nenajdenko


Publisher
John Wiley and Sons
Year
2006
Weight
20 KB
Volume
37
Category
Article
ISSN
0931-7597

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Bromo-1-alkenes were stereoselectively prepared in high yields in a short reaction time (0.2-1.0 min) by microwave irradiation of the corresponding 2,3-dibromoalkanoic acids in DMF in the presence of triethylamine.

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We describe a synthesis of 2E-pyrrole l-oxides (3) from the 3-bromopyrroline l-oxides (2). Bromination in the 3-position of 1-pyrroline l-oxides appears to be a general reaction and the 2-cyano-1-pyrroline l-oxides (1) undergo reaction with E-bromosuccinimide (NBS) to form the monobromo nitrones (2)