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Stereoselective Synthesis and in Vitro Antifungal Evaluation of (E)- and (Z)-Imidazolylchromanone Oxime Ethers

✍ Scribed by Saeed Emami; Mehraban Falahati; Ali Banifatemi; Kayvan Moshiri; Abbas Shafiee

Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 85 KB
Volume: 335
Category: Article
ISSN: 0365-6233
DOI: 10.1002/1521-4184(200209)335:7<318::aid-ardp318>3.0.co;2-o

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✦ Synopsis

A series of (E)- and (Z)-2, 3-dihydro-3-(1H-imidazol-1-yl)-4H-1-benzopyran-4-one oxime ethers have been synthesized and tested for antifungal activity. Most compounds showed moderate to potent in vitro antifungal activity. Among the tested compounds, compound (E)-3d was the most active agent against Candida albicans and Aspergillus niger, and compounds (Z)-(3a) and (E)-3a were the most potent compounds against Microsporum gypseum. Detailed stereoselective synthesis, spectroscopic, and biological data are reported.

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