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Stereoselective Synthesis and Biological Evaluation of Ferrocene-Containing 5-Hydroxyeicosatetraenoic Acid Analogues

✍ Scribed by Nina Kausch-Busies; Jörg Martin Neudörfl; Pascal Wefelmeier; Aram Prokop; Hartmut Kühn; Hans-Günther Schmalz


Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
861 KB
Volume
2011
Category
Article
ISSN
1434-193X

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Synthesis and biological evaluation of 9
✍ Mark Wall; Stephen J. Benkovic 📂 Article 📅 2002 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 35 KB

## Abstract The folate analogue, 9‐thia‐5,10‐dideazafolic acid (**3b**), was obtained in an efficient two‐step procedure in an overall yield of 60%. The previously unknown intermediate dimethyl‐thiocarbamic acid S‐(2‐amino‐3,4‐dihydo‐4‐oxo‐pyrido[2,3‐__d__]pyrimidin‐6‐yl) ester (**5**) was prepared