Stereoselective reactions of α,β-epoxy-aldehydes; the formation of “chelation controlled” products
✍ Scribed by Shouming Wang; Graham P. Howe; Ravinderjit S. Mahal; Garry Procter
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- French
- Weight
- 286 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
A study of the organometallic addition to α,β-epoxy aldehydes in ''non-chelation controlled'' conditions is reported. The conditions able to give the best stereoselectivities are used to prepare the Abbott amino diol.
## Abstract For Abstract see ChemInform Abstract in Full Text.
A study on the addition of boron enolates of methyl ketones to trans a,b-epoxy aldehydes is reported. The reaction proceeds with an excellent anti stereoselectivity, consistent with the Felkin-Ahn model, toward the synthesis of hydroxylated compounds with defined stereochemistry.