A Study on the “Non-Chelation Controlled” Organometallic Addition to trans α,β-Epoxy Aldehydes − A Straightforward Stereoselective Synthesis of the Abbot Amino Dihydroxyethylene Dipeptide Isoster

✍ Scribed by Giuliana Righi; Silvia Ronconi; Carlo Bonini

• Publisher: John Wiley and Sons
• Year: 2002
• Tongue: English
• Weight: 263 KB
• Volume: 2002
• Category: Article
• ISSN: 1434-193X
• DOI: 10.1002/1099-0690(200205)2002:9<1573::aid-ejoc1573>3.0.co;2-i

✦ Synopsis

A study of the organometallic addition to α,β-epoxy aldehydes in ''non-chelation controlled'' conditions is reported. The conditions able to give the best stereoselectivities are used to prepare the Abbott amino diol.