Chelation Control in the Ring Opening and Organometallic Addition of α,β-Epoxy Aldehydes: a New Entry to Amino Dihydroxyethylene Dipeptide Isostere Subunits

A Study on the “Non-Chelation Controlled

A Study on the “Non-Chelation Controlled” Organometallic Addition to trans α,β-Epoxy Aldehydes − A Straightforward Stereoselective Synthesis of the Abbot Amino Dihydroxyethylene Dipeptide Isoster

✍ Giuliana Righi; Silvia Ronconi; Carlo Bonini 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 263 KB

A study of the organometallic addition to α,β-epoxy aldehydes in ''non-chelation controlled'' conditions is reported. The conditions able to give the best stereoselectivities are used to prepare the Abbott amino diol.