𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Stereoselective preparation of DL-4-allohydroxyproline

✍ Scribed by H. C. Beyerman

Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
378 KB
Volume
80
Category
Article
ISSN
0165-0513

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A convenient preparation is described of DL‐4‐allohydroxyproline by reduction of DL‐4‐oxoproline with sodium borohydride in aqueous methanol. This reduction proceeds without appreciable formation of DL‐hydroxyproline, as shown by paper chromatography and by paper electrophoresis. The allo‐configuration of the reduction product (OH/COOH in cis‐position) was proved further by conversion of the latter into its lactone hydrobromide.

📜 SIMILAR VOLUMES

Short stereoselective synthesis of dl-al
Short stereoselective synthesis of dl-alloyohimbane and dl-epialloyohimbane
✍ Mauri Lounasmaa; Reija Jokela 📂 Article 📅 1990 🏛 Elsevier Science 🌐 French ⚖ 251 KB

A short and stereoselective synthesis for both aalloyohimbane and dl-epialloyohimbane using one and the same starting compound G presented. We recently developed a new synthetic methodlV3 which permits the preparation of l-, 2-and 3-monosubstituted 1,2, 3,4,6,7,12,12b-octahydroindolo[2,3-

Preparation of analogs of dl-tetrahydrom
Preparation of analogs of dl-tetrahydromethotrexate (4-amino-4-deoxy-N10-methyl-dl-5,6,7,8-tetrahydropterol-l-monoglutamic acid)
✍ J.A. Blair; K.J. Saunders 📂 Article 📅 1971 🏛 Elsevier Science 🌐 English ⚖ 238 KB

## 5-Alkyl derivatives of dl-tetrahydromethotrexate have been prepared by reduction of methotrexate by sodium borohydride followed by reductive condensation with aldehyde and sodium borohydride and formation of the calcium salt (l-3). ## Methods Chemicals were obtained as follows: methotrexate,

An improved method for the preparation o
An improved method for the preparation of DL 4-oxalysine
✍ G. I. Tesser; G. H. L. Nefkens 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 159 KB

## Abstract An improved synthesis of __DL__ 4‐oxalysine is described, with reference to the reactions outlined in the flow‐sheet.

A stereoselective synthesis of dl-3-epiu
A stereoselective synthesis of dl-3-epiuleine
✍ Mitsutaka Natsume; Yoshinori Kitagawa 📂 Article 📅 1980 🏛 Elsevier Science 🌐 French ⚖ 122 KB

A stereoselective synthesis of an indole alkaloid, 3-epiuleine, in racemic form is described. The key step involved is the ethylation of readily