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Stereoselective nitrilimine cycloadditions to the CN bond of enantiopure N-(1-phenylethyl)-1-arylmethanimines

✍ Scribed by Giorgio Molteni; Alessandro Ponti


Book ID
108283856
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
387 KB
Volume
15
Category
Article
ISSN
0957-4166

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Diastereoselective nitrilimine cycloaddi
✍ Giorgio Molteni; Gianluigi Broggini; Tullio Pilati πŸ“‚ Article πŸ“… 2002 πŸ› Elsevier Science 🌐 English βš– 255 KB

Enantiopure 1,4-benzodiazepin-4-one 1 and 1,4-benzodiazepin-6-ones 2 were reacted with hydrazonoyl chloride 8 in the presence of various basic agents. The diastereoselective 1,3-dipolar cycloaddition between the C N double bond of 1 or 2 and the nitrilimine intermediate 9 gave the enantiopure [1,2,4