An efficient enantioselective synthesis
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Masakazu Koiwa; Georges P.J Hareau; Fumie Sato
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Article
📅
2000
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Elsevier Science
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French
⚖ 99 KB
The asymmetric synthesis of the A-ring of 1α,25-dihydroxyvitamin D 3 , (Z)-2, from 5-tert-butyldimethylsiloxy-2-cyclohexenone [(S)-1], is described where an intramolecular lactonization using cat. scandium triflate is the key reaction.