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ChemInform Abstract: Enantioselective Synthesis of a Bicyclo(3.1.0)hexane A-Ring Synthon for 1α,25-Dihydroxyvitamin D3.

✍ Scribed by W. G. DAUBEN; T. A. LEWIS

Book ID
112025202
Publisher
John Wiley and Sons
Year
2010
Weight
32 KB
Volume
27
Category
Article
ISSN
0931-7597

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✍ Masakazu Koiwa; Georges P.J Hareau; Fumie Sato 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 99 KB

The asymmetric synthesis of the A-ring of 1α,25-dihydroxyvitamin D 3 , (Z)-2, from 5-tert-butyldimethylsiloxy-2-cyclohexenone [(S)-1], is described where an intramolecular lactonization using cat. scandium triflate is the key reaction.