## Abstract Pig liver esteraseβ(PLE) catalyzed hydrolysis of dimethyl esters of symmetrical dicarboxylic acids, including __meso__βdiacids, __cis__β1,2βcycloalkanedicarboxylic acids, and diacids with a prochiral center, was studied with 14 substrates. The products of these stereoselective hydrolyse
Stereoselective Hydrolysis of Substituted Cyclopropanedicarboxylates with Pig Liver Esterase
β Scribed by Paula Walser; Peter Renold; Victor N'Goka; Fatemeh Hosseinzadeh; Christoph Tamm
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- German
- Weight
- 767 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0018-019X
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The behaviour of dimethyl cis-and trans-4,5-epoxy-ds-1,2-cyclohexanedicarboxylate towards pig liver esterase (PLE) was studied. (1 R, 2S, 4S, SS)-4-Hydroxy-7-oxo-6-oxabicyclo[3.2.1]-octaneZ-carboxylic acid was formed.
The utilization of enzymes is a recent achievement in organic synthesis. There are many good reasons for the organic chemist to consider this approach. Enzymatic reactions are very fast and specific. The same transformations carried out by classical means in several days or weeks, can be achieved in