Stereoselective hydrolysis of the dimethyl 4,5-epoxy-1,2-cis-cyclohexanedicarboxylates with pig liver esterase (PLE)

✍ Scribed by Thomas Kuhn; Christoph Tamm; Andreas Riesen; Margareta Zehnder

• Publisher: Elsevier Science
• Year: 1989
• Tongue: French
• Weight: 229 KB
• Volume: 30
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)80284-7

✦ Synopsis

The behaviour of dimethyl cis-and trans-4,5-epoxy-ds-1,2-cyclohexanedicarboxylate towards pig liver esterase (PLE) was studied. (1 R, 2S, 4S, SS)-4-Hydroxy-7-oxo-6-oxabicyclo[3.2.1]-octaneZ-carboxylic acid was formed.