✦ LIBER ✦

Stereoselective Grignard-type reactions of chiral N,N-dibenzylamino ketones

✍ Scribed by Manfred T. Reetz; Alfred Schmitz

Book ID: 104261153
Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 230 KB
Volume: 40
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(99)00359-7

No coin nor oath required. For personal study only.

✦ Synopsis

N~V-Dibenzylamino ketones of the type Bn2N(RI)CHC(O)R 2, prepared in enantiomerically pure form from aamino acids, undergo non-chelation controlled Grignard-type reactions with RLi, RMgX or RCeCI2 without any undesired racemization.

📜 SIMILAR VOLUMES

ChemInform Abstract: Stereoselective Gri

ChemInform Abstract: Stereoselective Grignard-Type Reactions of Chiral N,N-Dibenzylamino Ketones.

✍ Manfred T. Reetz; Alfred Schmitz 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 35 KB 👁 1 views

## Stereoselective Grignard-Type Reactions of Chiral N,N-Dibenzylamino Ketones. -Enantiomerically pure N,N-dibenzylamino ketones (I), derived from chiral α-amino acids, react under nonchelating conditions with organometal reagents of type RLi, RMgX, RCeCl 2 . The reactions proceed highly diastere

Stereoselective reductive amination of c

Stereoselective reductive amination of chiral N,N-dibenzylamino ketones

✍ Manfred T. Reetz; Alfred Schmitz 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 129 KB

N,N-Dibenzylamino ketones of the type Bn2N(R)CHC(O)CH3, prepared in enantiomericaUy pure form from ~amino acids, undergo stereoselective reductive amination using PhCH2NHz/NaCNBH3 or NI-I4OAc/NaCNBH3 with formation of diastereo-and enantiomerically pure vicinal diamines Bn2N(R)CHCH(NHCH2Ph)CH3 or Bn

ChemInform Abstract: Stereoselective Red

ChemInform Abstract: Stereoselective Reductive Amination of Chiral N,N-Dibenzylamino Ketones.

✍ Manfred T. Reetz; Alfred Schmitz 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 33 KB 👁 1 views

Aldol reactions of α-(N,N-dibenzylamino)

Aldol reactions of α-(N,N-dibenzylamino) ethyl ketones

✍ Jane Betty Goh; Bharat R. Lagu; Julie Wurster; Dennis C. Liotta 📂 Article 📅 1994 🏛 Elsevier Science 🌐 French ⚖ 312 KB

Chemoselective preparation of ketones by

Chemoselective preparation of ketones by the grignard reaction of N-acylpyrazoles

✍ Choji Kashima; Isanobu Kita; Katsumi Takahashi; Akira Hosomi 📂 Article 📅 1995 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 202 KB

Boron-mediated aldol reactions of ethyl

Boron-mediated aldol reactions of ethyl α-(N,N)-dibenzylamino ketones: control of enolisation geometry and aldehyde π-facial selectivity

✍ Ian Paterson; Angela C Mackay 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 157 KB

The boron-mediated aldol reactions of a range of chiral a-(N,N)-dibenzylamino ketones with aldehydes can be controlled to provide stereodefined adducts. Complementary induction can be achieved with c Hex 2 BCl/Me 2 NEt leading to preferential formation of the 1,2-anti-2,4-syn adducts, while Bu 2 BOT