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Stereoselective enzymatic synthesis of an aspartame precursor of N-CBZ-l-Asp-l-PheOMe

✍ Scribed by Geun Hee Shin; Chulyoung Kim; Hyun Jung Kim; Chul Soo Shin


Book ID
113803682
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
85 KB
Volume
26
Category
Article
ISSN
1381-1177

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ChemInform Abstract: Practical Synthesis
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Practical Synthesis of an Enantiomerically Pure trans-4,5-Disubstituted 2-Pyrrolidinone via Enzymatic Resolution. Preparation of the LTB 4 Inhibitor BIRZ-227. -The efficient synthesis of rac. (II) in a simple one-pot procedure was already described. A novel enzymatic resolution of its rac derivative