Stereoselective distribution of hydroxychloroquine in the rabbit following single and multiple oral doses of the racemate and the separate enantiomers
β Scribed by Julie Ducharme; Dr. Irving W. Wainer; Heli I. Parenteau; John H. Rodman
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 809 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0899-0042
No coin nor oath required. For personal study only.
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Racemic ethotoin (lo00 mg) was administered orally as a single dose to six healthy adult volunteers. Blood samples were collected at appropriate times for 120 h following the dose. Ethotoin was quantified enantioselectively in plasma using a novel chiral column HPLC procedure. One of the enantiomers
## Abstract The pharmacokinetics of acebutolol have been studied in eight healthy male volunteers following the oral administration of acebutolol hydrochloride (βSectralβ, May & Baker) as a single dose (400 mg), and during and after repeated oral dosing (400 mg, b.d. for 56 days). Following single