Stereoselective binding of carbenicillin epimers to human serum albumin

✍ Scribed by Tomoo Itoh; Katashi Nakashima; Yasuyuki Tsuda; Hideo Yamada

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 602 KB
• Volume: 8
• Category: Article
• ISSN: 0899-0042
• DOI: 10.1002/(sici)1520-636x(1996)8:2<201::aid-chir5>3.0.co;2-l

✦ Synopsis

Binding of carbenicillin (CBPC) epimers to human serum albumin (HSA) was found to be stereoselective. Epimer-epimer interaction was also observed in the bmding to HSA. There were at least three binding sites on HSA for CBPC epimers, one of which (stereoselective site) was more in favor of S-CBPC than R-CBPC. At the stereoselective