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Stereoselective activation of vicinal dihalogen compounds to mutagens by glutathione conjugation

✍ Scribed by P.J. van Bladeren; A. van der Gen; D.D. Breimer; G.R. Mohn

Book ID
115774301
Publisher
Elsevier Science
Year
1979
Tongue
English
Weight
265 KB
Volume
28
Category
Article
ISSN
0006-2952

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✍ Vamvakas, Spyridon ;Herkenhoff, Martin ;Dekant, Wolfgang ;Henschler, Dietrich πŸ“‚ Article πŸ“… 1989 πŸ› John Wiley and Sons 🌐 English βš– 649 KB

The mutagenicity of tetrachloroethene (tetra) and its S conjugate, S-(1,2,2-trichlorovinyl)glutathione (TCVG) was investigated using a modified Ames preincubation assay. TCVG was a potent mutagen in presence of rat kidney particulate fractions containing high concentrations of y-glutamyl transpeptid