Stereocontrolled synthesis of α-2′-deoxyribonucleosides
✍ Scribed by Zhiwei Wang; Carmelo J Rizzo
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 225 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
A stereocontrolled synthesis of c¢-2'-deoxynucleosides has been achieved. Our synthetic strategy involves the use of a benzoyl group at the 2-position of arabinose as a directing group for Vorbrtiggen glycosylation and a deoxygenation precursor.
📜 SIMILAR VOLUMES
A new class of nucleotides, with one of the two non-bridging oxygens at or-phosphorus replaced by a borane (BH3) group, has shown potential applications in DNA sequencing. We have developed a convenient method for the synthesis of the 2'-deoxy-5'-(ot-P-borano)triphosphates of adenosine, guanosine, c
## Abstract The synthesis of 6‐substituted 1‐deazapurine 2′‐deoxyribonucleosides is described. Glycosylation of the 1‐deazapurine (imidazo[4,5‐__b__]pyridine) anions with the α‐D‐halogenose 5 gives stereoselectively __N__^7^‐ and __N__^9^‐ regioisomers. ^1^H‐NMR NOE and ^13^C‐NMR spectroscopy are u