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Stereocontrolled synthesis of tricyclic fused oxazolidinone as antibacterial agent

✍ Scribed by Yingjie Cui; Yaxian Dang; Yushe Yang; Ruyun Ji

Publisher
Journal of Heterocyclic Chemistry
Year
2006
Tongue
English
Weight
111 KB
Volume
43
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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Tricyclic fused oxazolidinone 3a and 3b have been synthesized as antibacterial agents in 12 and 11 steps respectively. The key intermediates 10a and 10b have been developed via opening of epoxide 9a and 9b and cyclization by the resulting oxygen anion attack.

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