Stereocontrolled synthesis of orthogonally protected 2-substituted 4-aminopiperidines
✍ Scribed by Badorrey, Ramón; Portaña, Elsa; Díaz-de-Villegas, María D.; Gálvez, José A.
- Book ID
- 118273939
- Publisher
- Royal Society of Chemistry
- Year
- 2009
- Tongue
- English
- Weight
- 179 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1477-0520
- DOI
- 10.1039/b904948g
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The highly diastereoselective conjugate addition of N-benzylhydroxylamineand bcrrzylarnine to ce#+maaturated taetam3 providedan efficiententryto enantiopurc (4S,5S)-4-amino-5-hydroxymethylpyrmlidin-2+mes. Q 1997131sevier ScienceLtd. Enantiomerically pure 4-arninopyrrolidin-2-onesare useful precurso
Schiff base derivatives of l-methyl(benzyl~-2,5-dimethylpiperidin-4-ones with phenyl, a-pyridyl, benzyl, and 8-hydroxyethyl substituents attached to the imine nitrogen atom react with organometallic compounds to give analogously substituted piperidlne bases with methyl, allyl, phenyl, and benzyl sub