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Stereocontrolled synthesis of novel phytosphingosine-type glucosaminocerebrosides

โœ Scribed by Teiichi Murakami; Kazuhiro Taguchi

Book ID
104209040
Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
1006 KB
Volume
55
Category
Article
ISSN
0040-4020

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โœฆ Synopsis

D-r/bo-Phytosphingosine I was conveniently synthesized from N-benzoyl-D-gluco~mnine $ by an improved route in which regioselective O-methanesulfonation and dias~ereoselective Grignard addition are involved as key steps. Using a synthetic intermediate of 1, novel D-rJbo-pbytosphingosinetype glycolipids 2a and 2b, unnatural homologues of antifungal cerebrosides Halicylindrosides, were efficiently synthesized in a stereoeontrolled mannar.

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