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Stereocontrolled Synthesis of Model Core Systems of Lomaiviticins A and B

โœ Scribed by K. C. Nicolaou; Ross M. Denton; Achim Lenzen; David J. Edmonds; Ang Li; Robert R. Milburn; Scott T. Harrison

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
262 KB
Volume
45
Category
Article
ISSN
0044-8249

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Stereocontrolled Synthesis of Model Core
Stereocontrolled Synthesis of Model Core Systems of Lomaiviticins A and B
โœ K. C. Nicolaou; Ross M. Denton; Achim Lenzen; David J. Edmonds; Ang Li; Robert R ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 261 KB

## on the occasion of his 60th birthday Lomaiviticins A (1) and B (2, Figure 1) were isolated in 2001 from the fermentation broth of a species of the actinomycete genus Micromonospora. [1] Both natural products were shown to be highly active DNA-damaging agents. The more abundant compound, lomaivit