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Stereocontrolled Solid-Phase Synthesis of Phosphorothioate Oligoribonucleotides Using 2′- O -(2-Cyanoethoxymethyl)-nucleoside 3′- O -Oxazaphospholidine Monomers

✍ Scribed by Nukaga, Yohei; Yamada, Kohei; Ogata, Toshihiko; Oka, Natsuhisa; Wada, Takeshi


Book ID
118043811
Publisher
American Chemical Society
Year
2012
Tongue
English
Weight
450 KB
Volume
77
Category
Article
ISSN
0022-3263

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Solid phase synthesis of oligoribonucleo
✍ Toshiki Tanaka; Masaya Orita; Seiichi Uesugi; Morio Ikehara 📂 Article 📅 1988 🏛 Elsevier Science 🌐 French ⚖ 510 KB

Oligoribonucleotides with chain length of 6-9 were synthesized on a polystyrene support using o-nitrobenzyl protection of 2'-hydroxyls via phosphotiriester method. The condensation reactions between N-acvl-5 and nucleoside bound to the resin using l-mesitylenesulfonyl-3-nitro-1H-1,2,4-triazole (MS