Stereocontrolled reductive amination of 3-hydroxy ketones

✍ Scribed by Mansour Haddad; Jérôme Dorbais; Marc Larchevêque

• Book ID: 104257701
• Publisher: Elsevier Science
• Year: 1997
• Tongue: French
• Weight: 178 KB
• Volume: 38
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(97)01349-x

✦ Synopsis

syn-l,3-Aminoalcohols are synthesized in high diastereomeric excess by reductive amination of 3-hydroxyketones with sodium cyanoborohydride in the presence of benzylamine.