First stereocontrolled synthesis and bio
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Aymeric Bordier; Philippe Compain; Olivier R. Martin; Kyoko Ikeda; Naoki Asano
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Article
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2003
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Elsevier Science
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English
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The first synthesis of 1,6-dideoxy-L-nojirimycin in enantiomerically pure form has been achieved in nine steps from L-xylose in an overall yield of 15%. The biological activity of this compound as a glycosidase inhibitor provided useful information on structure-activity relationships in the family o