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First stereocontrolled synthesis and biological evaluation of 1,6-dideoxy-l-nojirimycin

✍ Scribed by Aymeric Bordier; Philippe Compain; Olivier R. Martin; Kyoko Ikeda; Naoki Asano

Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
163 KB
Volume
14
Category
Article
ISSN
0957-4166

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✦ Synopsis

The first synthesis of 1,6-dideoxy-L-nojirimycin in enantiomerically pure form has been achieved in nine steps from L-xylose in an overall yield of 15%. The biological activity of this compound as a glycosidase inhibitor provided useful information on structure-activity relationships in the family of 1,5-iminoalditols.

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