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ChemInform Abstract: Synthesis and Biological Evaluation of a Series of 2′-Fluorinated-2′,3′-dideoxy-2′,3′-didehydro-(L)-nucleosides.

✍ Scribed by S.-H. CHEN; Q. WANG; J. MAO; I. KING; G. E. DUTSCHMAN; E. A. GULLEN; Y.-C. CHENG; T. W. DOYLE

Publisher: John Wiley and Sons
Year: 2010
Weight: 37 KB
Volume: 29
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199847257

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✦ Synopsis

Synthesis and Biological Evaluation of a Series of 2'-Fluorinated-2',3'-dideoxy-2',3'-didehydro-(L)-nucleosides.

-A general method for the synthesis of both the cis-and trans-2'-vinylfluoro containing nucleosides is presented. Among the nucleosides prepared compound (XI) displays the best biological activity. Interestingly, the incorporation of a fluorine atom at the 2'-position improves the cytotoxicity profile at the nucleoside, but fails to enhance its antiviral activity.

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