Stereochemistry of Enacyloxins. Part 4 : Complete Structural and Configurational Assignment of the Enacyloxin Family, a Series of Antibiotics from Frateuria sp. W-315

✍ Scribed by Hiroyuki Furukawa; Hiromasa Kiyota; Teiko Yamada; Manabu Yaosaka; Ryo Takeuchi; Toshihiko Watanabe; Shigefumi Kuwahara

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 123 KB
• Volume: 4
• Category: Article
• ISSN: 1612-1872
• DOI: 10.1002/cbdv.200790140

✦ Synopsis

Abstract

The absolute configurations of the enacyloxins, a series of polyhydroxylated polyene antibiotics from Frateuria species, were determined. The so far elusive (13′R,14′R,15′S)‐configuration was assigned to enacycloxin IVa (1) by means of ‘J‐resolved HMBC‐1’ and NOESY NMR methods.