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Stereochemistry-dependent inhibition of RAS farnesylation by farnesyl phosphonic acids

✍ Scribed by Raymond J. Hohl; Kriste A. Lewis; Diana M. Cermak; David F. Wiemer

Book ID
107489527
Publisher
Springer-Verlag
Year
1998
Tongue
English
Weight
248 KB
Volume
33
Category
Article
ISSN
0024-4201

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So far, treatment with anti-cancer agents has failed to achieve satisfactory results in hepatocellular carcinoma. In the process of hepatocarcinogenesis, ras has been shown to play a role. ras requires a farnesyl moiety for activation. It has been found that UCF I -C (manumycin). an antibiotic, inhi