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Stereochemical studies on medicinal agents. VII. Absolute stereochemistry of methadol isomers and the role of the 6-methyl group in analgetic activity

✍ Scribed by Portoghese, Philip S.; Williams, David Allen


Book ID
126461376
Publisher
American Chemical Society
Year
1969
Tongue
English
Weight
681 KB
Volume
12
Category
Article
ISSN
0022-2623

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Stereochemical Studies on Medicinal Agen
✍ Jacques H. Poupaert; Philip S. Portoghese πŸ“‚ Article πŸ“… 2010 πŸ› Wiley (John Wiley & Sons) βš– 198 KB πŸ‘ 2 views

## Abstract A CD study of 8 representatives of 4‐phenylpiperidine analgetics is presented to correlate their solid‐state conformations with their chiroptical properties in solution. In addition to the benzenoid ^1^L~b~ fingerprint, the studied compounds exhibit two waves: the former band around 230