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Stereochemical studies on medicinal agents. 12. Distinction of enantiotopic groups in the interaction of 1-methyl-4-phenyl-4-propionoxypiperidine with analgetic receptors

✍ Scribed by Larson, Dennis L.; Portoghese, Philip S.

Book ID: 121329647
Publisher: American Chemical Society
Year: 1973
Tongue: English
Weight: 584 KB
Volume: 16
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm00261a005

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Stereochemical Studies on Medicinal Agents. 24 Correlation of the Solid-State Conformations of 4-Phenylpiperidine Analgetic With the Torsional Relationship Between the Phenyl Group and Piperidine Ring in Solution, a Circular Dichroism Study

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## Abstract A CD study of 8 representatives of 4‐phenylpiperidine analgetics is presented to correlate their solid‐state conformations with their chiroptical properties in solution. In addition to the benzenoid ^1^L~b~ fingerprint, the studied compounds exhibit two waves: the former band around 230