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Stereochemical studies of the synthesis of α-amino-nitriles related to lincosamine

✍ Scribed by Czernecki Stanislas; Valery Jean-Marc

Book ID
107725692
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
617 KB
Volume
184
Category
Article
ISSN
0008-6215

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✍ AndréB Charette; Christophe Mellon 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 683 KB

The sequential addition of two different nucleophiles to a tartaric acid-derived nitrile produced carbinamines. The adducts from chelation-controlled addition which are obtained in high diastereoselectivities and yields, were easily converted to ct,ct-disubstituted-t~-amino acids.