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Novel and efficient transformation of α-amino nitrile to α-imino and α-amide nitriles in asymmetric Strecker synthesis

✍ Scribed by Kosuke Namba; Masanori Kawasaki; Ichinori Takada; Seiji Iwama; Masashi Izumida; Tetsuro Shinada; Yasufumi Ohfune


Book ID
104230617
Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
133 KB
Volume
42
Category
Article
ISSN
0040-4039

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## Abstract The synthesis of optically pure chloromethyl (−)‐menthyl ether (2b) and its use in the synthesis of di‐(−)‐menthyl acetal (−)‐menthyl (+)‐menthyl acetals are described. The diastereomeric mixed acetals 7a, b and 8a, b are easily obtainable from the nitrones 5 and 6, KCN and 2b. The mixt