Stereochemical aspects of diphenylbisbenzylisoquinoline alkaloids from Tiliacora racemosa
β Scribed by A.K. Ray; G. Mukhopadhyay; S.K. Mitra; Biswapati Mukherjee; A. Nelofer; Atta-ur-Rahman
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 161 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0031-9422
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A muscarinic alkaloid with a quaternary nitrogen was isolated from Trophis racemosa. Aqueous solutions (0.5%-2%) of the chloride salt of the alkaloid produced dose-dependent reductions of intra-ocular pressure ranging from 6.6 AE 0.7 mmHg to 15.7 AE 0.3 mmHg, (p `0.001, n = 5) in dogs. Atropine (0.1
An analysis of the l3 C NMR spectra of bisbenzylisoquinoline alkaloids of the berbamine type shows the dependence of spectroscopic properties on preferred conformation. Apart from the interesting pharmacological activity shown by some members2, the bisbenzylisoquinoline alkaloids form a particularly