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Stereochemical aspects and 13C NMR spectroscopy of the berbamine class of bisbenzylisoquinoline alkaloids

✍ Scribed by Luzia Koike; Anita J. Marsaioli; Edmundo A. Rúveda; Francisco de A.M. Reis; I. Ralph; C. Bick

Publisher
Elsevier Science
Year
1979
Tongue
French
Weight
259 KB
Volume
20
Category
Article
ISSN
0040-4039

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✦ Synopsis

An analysis of the l3 C NMR spectra of bisbenzylisoquinoline alkaloids of the berbamine type shows the dependence of spectroscopic properties on preferred conformation. Apart from the interesting pharmacological activity shown by some members2, the bisbenzylisoquinoline alkaloids form a particularly attractive group for studying the interrelationship between preferred conformation and spectroscopic properties, as a result of the rather inflexible rings possessed by the majority of these bases. In continuation of our project on isoquinoline alkaloids3'4, we have accordingly selected the berbamine class for an exhaustive 13C NMR spectroscopic analysis. A correlation of the spectra of phaeanthine &, tenuipine l&,

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