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Stereo- and regio-selective Ti-mediated radical cyclization of epoxy-alkenes: synthesis of the A and C ring synthons of paclitaxel

✍ Scribed by Kazuoki Nakai; Miyuki Kamoshita; Takayuki Doi; Haruo Yamada; Takashi Takahashi

Book ID
104231703
Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
62 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

We have developed a practical synthetic route for the A and C rings of paclitaxel. The key reaction is a Ti-mediated radical cyclization of an epoxyalkene.

πŸ“œ SIMILAR VOLUMES

ChemInform Abstract: Stereo- and Regio-s
ChemInform Abstract: Stereo- and Regio-selective Ti-Mediated Radical Cyclization of Epoxy-Alkenes: Synthesis of the A and C Ring Synthons of Paclitaxel.
✍ Kazuoki Nakai; Miyuki Kamoshita; Takayuki Doi; Haruo Yamada; Takashi Takahashi πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 30 KB πŸ‘ 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a β€œFull Text” option. The original article is trackable v

An efficient synthesis of optically acti
An efficient synthesis of optically active five- and six-membered cyclic compounds with selectable stereo-controls by a Ti(II)-mediated cyclization of chiral secondary 2,7- and 2,8-enyn-1-ol derivatives
✍ Yongcheng Song; Yuuki Takayama; Sentaro Okamoto; Fumie Sato πŸ“‚ Article πŸ“… 2003 πŸ› Elsevier Science 🌐 French βš– 376 KB

Ti(II)-mediated cyclization of readily accessible optically active secondary 2,7-and 2,8-enyn-1-ol derivatives enables the selective preparation of any one of the four possible stereoisomers of the cyclized product with high optical purity.