Stepwise Synthesis of Siloxane-Substituted Oligophosphanes Pn[O(iPr2Si)2]2 (n = 2, 4)
✍ Scribed by Andreas Kracke; Carsten von Hänisch
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 595 KB
- Volume
- 2011
- Category
- Article
- ISSN
- 1434-1948
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## Abstract The 5‐methyl(^15^N~2~)[__O__^2^,__O__^4^‐^17^O~2~]uridine (= (^15^N~2~)[__O__^2^,__O__^4^‐^17^O ~2~]ribosylthymine; 15) was synthesized and analyzed by ^15^N‐ and ^17^O‐NMR spectroscopy. (^15^N~2~)Urea was condensed with 2,3‐dibromo‐2‐methylpropanoyl chloride (3) and cyclized to form (^
## Abstract A general synthetic approach for the synthesis of ^15^N‐ and ^17^O‐doubly labelled pyrimidine nucleosides is described. The ^15^N isotopes in uridine and the ^17^O isotope in the urea‐derived carbonyl group of uridine and cytidine originate from (^15^N~2~)[^17^O]urea (5) which was synth
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