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Stem cells engineered to express self-antigen to treat autoimmunity

✍ Scribed by Frank Alderuccio; Kim Murphy; Ban-Hock Toh


Book ID
117787356
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
158 KB
Volume
24
Category
Article
ISSN
1471-4906

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Inducing apoptosis of activated lymphocytes via Fas ligand (FasL, CD95) may be a useful strategy for the treatment of autoimmune diseases mediated by pathogenic T cells. We propose that B cells may be ideal tools for effective delivery of a FasL-mediated apoptotic signal to pathogenic T cells for a