Stem Cell-Based Therapy for Lung Disease

✍ Scribed by Janette K. Burgess, Irene H. Heijink

• Publisher: Springer International Publishing
• Year: 2019
• Tongue: English
• Leaves: 260
• Edition: 1st ed. 2019
• Category: Library

✦ Synopsis

This book presents state-of-the-art pre-clinical models and clinical applications of stem-cell-based therapies applied to different lung diseases, with a special focus on the translation of bench data into clinical studies.

Starting with the assumption that abnormal lung tissue repair and regeneration has emerged as the driving force underlying pathogenesis and progression in many lung diseases, it sheds new light on the potential of stem/stromal cells as drivers of repair and sources of reparative factors in the lung.

The first part of the book offers an overview of stem cell types and mechanisms involved in lung development, homeostasis, repair and regeneration, and reveals the crucial role of the extracellular matrix within the lung microenvironment. In the second part, leading experts present the latest pre-clinical evidence and clinical applications of stem-cell-based therapies in a wide variety of lung diseases, ranging from COPD and lung fibrosis to other rare lung diseases. The last section discusses stem cell delivery systems and devices, such as aerosolised spray application.

This book appeals to pneumologists, stem cell and matrix biologists, as well as bioengeneers with a special interest in regenerative medicine applied to pulmonary diseases.

✦ Table of Contents

Front Matter ....Pages i-viii
Chronic Lung Pathologies That Require Repair and Regeneration (Roderick de Hilster, Minghui Li, Wim Timens, Machteld Hylkema, Janette K. Burgess)....Pages 1-12
Front Matter ....Pages 13-13
Stem/Progenitor Cell Populations Resident in the Lung and the Role of Stromal Support in Their Maintenance and Differentiation (Irene H. Heijink, Nick H. T. ten Hacken)....Pages 15-34
Comparison of the Regenerative Potential for Lung Tissue of Mesenchymal Stromal Cells from Different Sources/Locations Within the Body (Sara Rolandsson Enes, Gunilla Westergren-Thorsson)....Pages 35-55
The Potential of Factors Released from Mesenchymal Stromal Cells as Therapeutic Agents in the Lung (Fernanda Ferreira Cruz, Patricia Rieken Macedo Rocco)....Pages 57-70
Front Matter ....Pages 71-71
Preclinical Evidence for the Role of Stem/Stromal Cells in COPD (Deniz A. Bölükbas, Iran Augusto Neves Da Silva, Kristina Rydell-Törmänen, Darcy E. Wagner)....Pages 73-96
Clinical Application of Stem/Stromal Cells in COPD (Sara Rolandsson Enes, Juan J. Uriarte, Robert A. Pouliot, Daniel J. Weiss)....Pages 97-118
Stem Cell Based Therapy for Lung Disease Preclinical evidence for the role of stem/stromal cells Clinical application of stem/stromal cells in lung fibrosis (Carissa L. Patete, R. L. Toonkel, Marilyn Glassberg)....Pages 119-130
Paving the Road for Mesenchymal Stem Cell-Derived Exosome Therapy in Bronchopulmonary Dysplasia and Pulmonary Hypertension (Vincent Yeung, Gareth R. Willis, Elizabeth Taglauer, S. Alex Mitsialis, Stella Kourembanas)....Pages 131-152
CRISPR/Cas9 Editing in Induced Pluripotent Stem Cells: A Way Forward for Treating Cystic Fibrosis? (Erik J. Quiroz, Amy L. Ryan (Firth))....Pages 153-178
Clinical Application of Stem/Stromal Cells in Cystic Fibrosis (Steven T. Leung, Timothy S. Leach, Anthony Atala, Sean V. Murphy)....Pages 179-198
Preclinical Evidence for the Role of Stem/Stromal Cells in Targeting ARDS (Tamara Cruz, Mauricio Rojas)....Pages 199-217
The Safety and Efficiency of Addressing ARDS Using Stem Cell Therapies in Clinical Trials (Emanuele Rezoagli, Emma J. Murphy, John Laffey, Daniel O’Toole)....Pages 219-238
Front Matter ....Pages 239-239
Stem Cell Delivery Systems and Devices - Spraying (Sally Yunsun Kim, Wojciech Chrzanowski)....Pages 241-253
Front Matter ....Pages 255-255
Challenges and Opportunities for the Future of Stem Cell Therapy for Lung Diseases (Irene H. Heijink, Janette K. Burgess)....Pages 257-259

✦ Subjects

Life Sciences; Stem Cells; Pneumology/Respiratory System